Search results for "ascending aorta aneurysm"

showing 6 items of 6 documents

Genotyping strategy of SMAD-3 rs3825977 gene variant for a differential management of ascending aorta aneurysm in women people: Gender oriented diagn…

2020

Abstract Background and objectives The research of opportune strategies for facilitating the management of complex pathologies, such as ascending aorta aneurysm (AAA), currently represents the principal object of clinicians, clinical pathologists included. Herein, we propose genotyping of gene variants related to TGF-β pathway as useful strategy to improve the complex AAA management, exclusively based on imaging evaluations. Precisely, we investigated four functional SNPs in SMAD and VEGF genes, encoding molecules able to modulate functions and cross-talks of TGF-β pathway. Populations and methods Our study included 92 individuals (70 men (76%) and 22 (24%) women; mean age: 71.4 ± 2.6 years…

0301 basic medicinetransforming growth factorSNPs of SMAD and VEGF genesSMADBioinformaticsAscending aorta aneurysm (AAA)03 medical and health sciences0302 clinical medicineImmune systemmedicine.arteryGenotypeGeneticsmedicineGenotypingGeneGenetics (clinical)aorta aneurysmMetalloproteinaseAortaFemale peoplebusiness.industryGenetic variantsaorta aneurysm; transforming growth factorSettore MED/23030104 developmental biology030220 oncology & carcinogenesisGender medicinebusinessGenotyping strategy
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Risk of aortic dissection in patients with ascending aorta aneurysm: a new biological, morphological, and biomechanical network behind the aortic dia…

2020

Thoracic aortic aneurysm represents a deadly condition, particularly when it evolves into rupture and dissection. Proper surgical timing is the key to positively influencing the survival of patients with this pathology. According to the most recent guidelines, ascending aorta size ≥ 55 mm and a rate of growth ≥ 0.5 cm per year are the most important factors for surgical indication. Nevertheless, a lot of evidence show that aortic ruptures and dissections might occur also in small size ascending aorta. In this review, we sought to analyze a new biological and morphological network behind the aortic diameter that need to be considered in order to identify the portion of patients with thoracic…

Aortic dissectionSettore MED/23business.industrymedicineIn patientAnatomyAscending aorta aneurysmAortic diameterCardiology and Cardiovascular Medicinemedicine.diseasebusinessAscending aorta aneurysm ascending aorta size aortic dissection genetic risk factors morphological aspects surgical indication for aortic repair
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Deregulation of Notch1 pathway and circulating endothelial progenitor cell (EPC) number in patients with bicuspid aortic valve with and without ascen…

2018

AbstractBicuspid aortic valve (BAV) is frequently associated with the development of ascending aortic aneurysm, even if the underlying mechanisms remain to be clarified. Here, we investigated if a deregulation of Notch1 signaling pathway and endothelial progenitor cells (EPCs) number is associated with BAV disease and an early ascending aortic aneurysm (AAA) onset. For this purpose, 70 subjects with BAV (M/F 50/20; mean age: 58.8 ± 14.8 years) and 70 subjects with tricuspid aortic valve (TAV) (M/F 35/35; mean age: 69.1 ± 12.8 years) and AAA complicated or not, were included. Interestingly, patients with AAA showed a significant increase in circulating Notch1 levels and EPC number than subje…

Male0301 basic medicineAortic valveNotch1 signaling pathwatHeart Valve Diseases030204 cardiovascular system & hematologyAortic aneurysm0302 clinical medicineBicuspid aortic valveBicuspid Aortic Valve DiseaseNotch Signaling Pathwaycirculating EPC populationsReceptor Notch1ReceptorAortaEndothelial Progenitor CellsAged 80 and overMultidisciplinaryQRMiddle AgedAortic Aneurysmmedicine.anatomical_structureAortic Valvecardiovascular systemCardiologyMedicineFemaleTricuspid ValveSignal TransductionAdultmedicine.medical_specialtyBicuspid aortic valveEndothelial Progenitor Cells (EPC)ScienceNotch signaling pathwayBicuspid Aortic Valve (BAV)Endothelial progenitor cellArticleBicuspid aortic valve; Notch1 signaling pathwat; ascending aortic aneurysm03 medical and health sciencesascending aortic aneurysmInternal medicinemedicineHumansIn patientcardiovascular diseasesProgenitor cellNotch 1 signaling pathwayAgedTricuspid Aortic Valve (TAV)Ascending Aorta Aneurysm (AAA)business.industrySettore MED/23 - Chirurgia Cardiacamedicine.disease030104 developmental biologybusiness
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The Endothelial Transcription Factor ERG Mediates a Differential Role in the Aneurysmatic Ascending Aorta with Bicuspid or Tricuspid Aorta Valve: A P…

2022

The pathobiology of ascending aorta aneurysms (AAA) onset and progression is not well understood and only partially characterized. AAA are also complicated in case of bicuspid aorta valve (BAV) anatomy. There is emerging evidence about the crucial role of endothelium-related pathways, which show in AAA an altered expression and function. Here, we examined the involvement of ERG-related pathways in the differential progression of disease in aortic tissues from patients having a BAV or tricuspid aorta valve (TAV) with or without AAA. Our findings identified ERG as a novel endothelial-specific regulator of TGF-β-SMAD, Notch, and NO pathways, by modulating a differential fibrotic or calcified A…

NotchHeart Valve DiseasesCatalysisInorganic ChemistryBicuspid Aortic Valve DiseaseTranscriptional Regulator ERGascending aorta aneurysm; bicuspid aorta valve; tricuspid aorta valve; ERG transcriptional factor pathway; TGF-β-SMAD; Notch; NO pathways modulationTransforming Growth Factor betaSettore MED/05 - Patologia ClinicaHumansTGF-β-SMADEndotheliumPhysical and Theoretical ChemistryMolecular BiologySpectroscopyAortabicuspid aorta valveOrganic ChemistryERG transcriptional factor pathwayGeneral Medicineascending aorta aneurysmComputer Science ApplicationsSettore MED/23Aortic Valvetricuspid aorta valveNO pathways modulationBiomarkersTranscription FactorsInternational Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10848
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CRT-723 Is the Sporadic Thoracic Aortic Aneurysm the Result of an Inflammatory Process?

2014

Sporadic thoracic aortic aneurysm (S-TAA) is potentially devastating with severe morbidity and mortality. The histopathologic underlying abnormality of both ascending aortic aneurysm and dissection is medial degeneration, a pathological entity initially described as no inflammatory lesions of smooth

medicine.medical_specialtybusiness.industryMedial degenerationSettore MED/23 - Chirurgia CardiacaDissection (medical)medicine.diseaseThoracic aortic aneurysmmetalloproteinasesAortic aneurysmcardiovascular systemmedicineAscending aorta aneurysm metalloproteinases angiotensin converting enzymeSevere morbiditycardiovascular diseasesRadiologyAbnormalityCardiology and Cardiovascular MedicinebusinessPathologicalProcess (anatomy)Ascending aorta aneurysmangiotensin converting enzymeJACC: Cardiovascular Interventions
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Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascend…

2022

Aorta diseases, such as ascending aorta aneurysm (AsAA), are complex pathologies, currently defined as inflammatory diseases with a strong genetic susceptibility. They are difficult to manage, being insidious and silent pathologies whose diagnosis is based only on imaging data. No diagnostic and prognostic biomarkers or markers of outcome have been known until now. Thus, their identification is imperative. Certainly, a deep understanding of the mechanisms and pathways involved in their pathogenesis might help in such research. Recently, the key role of oxidative stress (OS) on the pathophysiology of aorta disease has emerged. Here, we describe and discuss these aspects by revealing some OS …

potential biomarkersPhysiologyClinical Biochemistryaorta diseasesascending aorta aneurysm (AsAA)Cell Biologybenefits and limitationsreactive oxygen species (ROS)BiochemistrySettore MED/23oxidative stressSettore MED/05 - Patologia Clinicapotential treatmentsMolecular BiologyAntioxidants (Basel, Switzerland)
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